Zebrafish: Lifeline for Damaged Heart

 

Context: Scientists at Pune-based Agharkar Research Institute conducting research on Zebrafish, for its ability of heart regeneration.

 

 


Background:  Scientists have found that Zebrafish which is a tiny fish and found in the freshwater ecosystem is able to regenerate its damaged heart in a very short period of time. Prevalent in the South Asian region, the fish is sold in the aquariums and also known by its trade name Danio.

 

Scientists at the Pune based Agharkar Research Institute have in a study identified the genes found in the fish that helps it to regenerate the damaged part of its heart.

 

 

Zebrafish

 

The species is a tiny one about 2-3 cm long and is found in abundance in tropical and subtropical regions of the planet. The fish is also considered to be an indigenous species to the Indo-Gangetic plains of India, where they are found in large numbers in the water filled paddy fields along with streams and stagnant water bodies.

 

The fish has a very short lifespan of about 2-3 years in laboratory conditions and it becomes adult within weeks after it is born. What makes the fish an attractive proposition for the scientific community is its transparent body through which one can easily spot various body organs of the fish including heart and blood circulation.

 

 

 

Point of Research

 

 

Heart diseases and blood circulation diseases are the cause for the death of the largest number of people globally. Humans do not have the ability to regenerate their damaged heart organ unlike their liver or skin.

 

In mammals, including humans, the heart muscle has a very limited capacity to recover after injury. After an acute myocardial infarction, millions of cardiac muscle cells, named cardiomyocytes, die, and are replaced by a scar.

 

Unlike mammals, other vertebrates (Having spinal cord surrounded by cartilage or bone) can recover much better from a cardiac damage. This is the case of some fish, including the zebrafish, a well-established animal model in biomedical research which shares with humans most of its genes.

 

Zebrafish are extremely well suited to study organ regeneration. After heart injury, zebrafish cardiomyocytes can divide and the scar is replaced by new cardiac muscle. The group of Scientist from Puna, has been interested in understanding the cellular mechanisms of heart regeneration during the last 10 years.

 

Now the researchers show that not all cardiomyocytes in the zebrafish heart contribute equally to regenerate the lost muscle, but that there is a specific subset of cardiomyocytes with enhanced regenerative capacity.

 

 

Matter of Genetics

 

 

Scientists used Zebra fish to identify the genes or corresponding proteins that promote heart regeneration and its working model. After a restless study of many years, Scientist identify the cellular communication network factor 2a (ccn2a), a gene that can promote heart regeneration by enhancing cardio-myocyte proliferation.

 

Ccn2a promotes the innate regenerative response of the adult zebrafish heart and maybe a promising therapeutic target for humans. The identified gene, which can promote heart regeneration, can enhance the proliferation of functional contractile heart cells called cardio-myocytes.

 

It is also observed that this gene resolves the transient collagenous fibrotic scar resulting in faster regeneration. Although, the investigation on the molecular pathways responsible for faster heart regeneration is still ongoing.

 

 

Significance for humans

 

Cardiovascular diseases are the number 1 cause of deaths globally, taking an estimated 17.9 million lives each year, according to the World Health Organisation.

 

Humans cannot regenerate their hearts like skin or liver. Humans cannot regenerate their hearts upon myocardial damage and a person who suffered a heart attack cannot functionally heal the damaged heart muscle, resulting in reduced pumping efficiency.

 

While on the other hand, this unique fish has the full potential to regenerate its heart and restore its function after injury.

 

Till now, there is no treatment available to restore the damaged heart function in humans. Hence scientists have sought to decode the heart regeneration processes using this model animal, which can naturally regenerate their hearts efficiently so as to understand the processes which can illuminate strategies to improve human cardiac regeneration.

 

 

Conclusion

 

The breakthrough in finding the gene in the Zebrafish will help understand scientists to understand the mechanism of heart regeneration and look at the possibilities of making it possible for humans.

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